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KMID : 0379520080240020109
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한국독성학회지
2008 Volume.24 No. 2 p.109 ~ p.112
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Association of the G134A and G184C Polymorphisms in the CYP1A1 Gene with Lung Cancer Incidence
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Ryu Doug-Young
Huang Mingai
Park Chang-Bo
Chang Soo-Im
Im Ruth
Choi Seong-Jin
Kim Na-Young
Park In-Won
Choi Byoung-Whui
Kim Jae-Yeol
Shin Jong-Wook
Choi Jae-Cheol
Choi Byung-Sun
Park Jung-Duck
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Abstract
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The G184C and G134A single nucleotide polymorphisms (SNPs) of the CYP1A1 gene result in Ala62Pro and Gly45Asp substitutions, respectively. Here, we tested whether these SNPs are associated with an alteration in lung cancer incidence. We examined 80 Korean subjects with lung cancer and 240 age- and sex-matched controls. For each subject, the CYP1A1 gene was PCR amplified and sequenced. We observed that the odds ratio (OR) for lung cancer was 3.37 higher in subjects with the G184C polymorphism than in controls (95% confidence interval (CI), 0.89~12.73, P = 0.07). In contrast, the OR for lung cancer was 1.23 in subjects with the G134A polymorphism compared to controls (95% CI, 0.68~2.20, P = 0.49). The G184C polymorphism exacerbated the effects of smoking on lung cancer development. Gene-smoking interaction analyses revealed that past or present smokers with the G184C polymorphism had a higher incidence of lung cancer (OR, 24.72; 95% CI, 4.48~136.31; P ＜ 0.01) than control smokers (OR, 6.65; 95% CI, 2.72~16.28; P ＜ 0.01). However, there was only a slight difference in the ORs for lung cancer between control smokers and smokers with the G134A polymorphism. These findings suggest that the G184C polymorphism, but not the G134A polymorphism, is associated with an increased risk of lung cancer.
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KEYWORD
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CYP1A1, Single nucleotide polymorphism, G134A, G184C, Gly45Asp, Ala62Pro, Lung cancer
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